At SoCal Biosciences, we support drug discovery from early research to clinical development with unparalleled expertise. Specializing in advanced bioanalytical services for mRNA, oligonucleotides, and large molecules across diverse therapeutic areas, our team leverages over 3 decades of collective experience in the field.
Our scientists create custom bioanalytical / analytical methods using advanced technologies like Branched DNA (bDNA), quantitative PCR (qPCR), Meso Scale Discovery (MSD), Enzyme-Linked Immunosorbent Assay (ELISA), and Liquid Chromatography Mass Spectrometry (LC-MS/MS). We meticulously design and optimize assays with our experienced team to deliver reliable results across complex research landscapes. Each method is tailored to meet your specific needs with precision and accuracy.
At SoCal Biosciences, we provide fit-for-purpose assays designed to meet the unique needs of each client. Our assays are tailored to align with the stage of drug development and regulatory requirements, ensuring accurate and meaningful data at every phase.
Our flexible bioanalytical approach allows for early insights in drug discovery and development, enabling informed decision-making and optimizing program success. As part of our feasibility assessment, we evaluate assay performance, sensitivity, and robustness to determine the most suitable bioanalytical strategy. Whether in feasibility studies or advanced validation, our methods are designed to deliver reliable, high-quality results that support the progression of your therapeutic programs.
Our team follows rigorous protocols for handling a wide range of biological samples, including but not limited to whole blood, plasma, serum, urine, saliva, cerebrospinal fluid, tissue specimens, PBMC, primary cells, and cell lines. We preserve sample integrity using specialized techniques that maintain molecular characteristics. Minimizing variability is our top priority across different studies.
We provide accurate, high-quality data using advanced analytical techniques in various areas including qPCR, bDNA, ViewRNA ISH, in vitro cell-based, immunogenicity, biomarkers, oligonucleotide screening, mRNA process impurity quantification, protein quantification, and beyond. Complementing our expertise, our comprehensive quality control process ensures the highest standards of precision and reliability.
At SoCal Biosciences, we provide comprehensive documentation and support to ensure smooth transition of methods to clients and other service providers. Our robust assay and transparent approach minimize potential issues and accelerate your timeline—making method transfer seamless and efficient.
Regulatory compliance is at the core of our bioanalytical services. At SoCal Biosciences, we are committed to qualifying and validating all methods to meet stringent FDA and Good Laboratory Practice (GLP) standards. Our services will be fully GLP-compliant by Q2 2025. With rigorous documentation and a focus on continual improvement, we ensure robust evidence for successful regulatory submissions.
SoCal Biosciences offers strategic guidance on study design and regulatory navigation. We provide expert problem-solving that goes beyond method development, sample analysis, and data analysis, helping you interpret and leverage insights for maximum scientific impact. Even after project completion, we remain committed to supporting you throughout the submission process and addressing any future questions, ensuring smooth transitions and ongoing success.
SoCal Biosciences partners with biotech and pharmaceutical companies, mRNA contract manufacturing organizations, startups, and government agencies. From early-stage research to drug development phases, we work with organizations globally in all phases of research and drug development. Our approach is grounded in innovation, reliability, and trust, offering flexible strategies and competitive pricing to meet your project requirements. We provide equal commitment no matter the size of your projects.
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Want to learn more about SoCal Biosciences? Here are answers to common questions about our bioanalytical services as a trusted CRO.
We specialize in RNA and oligonucleotide quantification, protein quantification, lipid quantification, in vitro cell-based, immunogenicity and biomarkers, and potency assays using advanced technology.
Yes, we create tailored assays to meet your unique research goals, leveraging the latest technology for sensitivity, precision, and accuracy.
Absolutely. With our high-throughput instruments and experienced team, we are equipped to handle projects of any size while maintaining the highest standards of quality and efficiency. Our track record includes the successful execution of numerous large-scale projects, with no delays and 100% client satisfaction.
We understand the CRO pain points from the perspective of drug developers. By combining cutting-edge technology, deep expertise in RNA, oligonucleotide, and protein drug development, along with a commitment to personalized service, we deliver exceptional bioanalytical support that meets the highest quality standards and client expectations.
SoCal Biosciences is led by Patty Limphong, who has over 10+ years of experience in RNA drug development and therapeutics and expertise in bioanalytical assays for mRNA and oligonucleotides.
Patty and her team at SoCal Biosciences have supported multiple clients with RNA and protein assay development and quantitation for many drug development projects approved by IND and CTA for initiating clinical trials. Some of the data was used for regulatory submission for the first commercialized sa-mRNA COVID-19 vaccine.
SoCal Biosciences is a trusted choice for RNA-related projects due to its meticulous approach to RNA analysis, its commitment to maintaining an RNase-free environment, and a highly experienced team specializing in RNA bioanalysis and drug development. The facility features a dedicated workspace exclusively for RNA work, supported by specialized personal protective equipment (PPE) such as masks, lab clothes, and gloves reserved for RNA-related tasks. Additionally, the lab uses dedicated pipettes with filtered tips, certified RNase-free materials and reagents, and RNA-specific extraction equipment to ensure accuracy and reliability. Temperature control is carefully maintained during sample processing and storage, ensuring long-term preservation of RNA samples. These rigorous standards, combined with our expert team’s deep knowledge in RNA bioanalysis and drug development, make SoCal Biosciences an ideal partner for RNA-focused research.
At SoCal Biosciences, every data set undergoes a multi-level quality control process and management review to ensure data integrity.
Client Voices: Stories of Trust and Excellence
“At TriLink Biotechnologies, our mission as an RNA-focused CDMO is to enhance the efficacy and safety of mRNA medicines. In our pursuit of this goal, we found an invaluable partner in SoCal Biosciences. Their expertise in cell culture, expression analysis, and immunogenicity proved instrumental in our collaborative effort to screen a variety of novel RNA chemical moieties. SoCal Biosciences went above and beyond in developing and optimizing expression assays across multiple cell lines, efficiently screening dozens of molecules using both standardized and complex pre-treatment regimens. Their thorough data analysis was crucial in helping us swiftly identify the most promising candidate molecules for further development.”
“I have been in the nonclinical drug development space for 30+ years and Patty is one of the most intelligent scientists I have ever met! I have worked with her for 6+ years and am constantly amazed at how fast she is able to tackle new challenges. She is a proven expert in mRNA bioanalytical assays. She has set up very complicated assays for me and generated data that has supported clinical trials and have been part of multiple regulatory documents, including marketing applications. I have now worked with SoCal Biosciences and am pleased to see the same scientific expertise attention to detail. As I have come to expect from working with Patty, SoCal Biosciences consistently delivers excellent support, and I appreciate the team’s willingness to “go the extra mile”. If you have a novel complicated assay, SoCal Biosciences is your CRO!!!”
“Patty Limphong, founder of SoCal Biosciences, runs a world-class CRO for mRNA drug development. We have had great success running dot blots to measure dsRNA and receiving services and consultation around mRNA sequence design, mRNA synthesis, and safety/toxicology studies. Patty and the SoCal Biosciences team are leading experts in RNA bioanalytical work, performing all of their services with high quality, excellent communication, rapid turnaround time, and competitive pricing. I would highly recommend working with SoCal Biosciences.”
“We have relied on SoCal Biosciences to support multiple nonclinical studies and clinical programs. The quality and reliability of their work for our company have consistently exceeded our expectations. Their services are reasonably priced, communication is excellent, and they always complete projects on time. We are very pleased with their services.”